PIGA

Across TCGA pan-cancer cohorts, PIGA Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PIGA data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PIGA Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIGA expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

COAD and SKCM are the cancer types where PIGA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.150	0.700	<.001	18	view →
SKCM	DFS	Median	All	1.000	0.200	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PIGA–COAD (DFS)

Open the COAD breakdown →