PIGA

Across TCGA pan-cancer cohorts, PIGA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PIGA data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PIGA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIGA expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where PIGA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.480	0.916	.001	51	view →
PDAC	OS	Quartile	All	0.230	0.648	.009	17	view →
LSCC	OS	Median	All	1.000	0.927	.010	13	view →
GBM	OS	Quartile	All	0.244	0.554	.024	6	view →
LUAD	DFS	Median	All	0.653	0.957	.007	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PIGA–HNSC (DFS)

Open the HNSC breakdown →