PIGA

Across TCGA patient cohorts, PIGA protein abundance is significantly associated with the RNA expression of many other genes, with 2,832 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PIGA-associated genes across cancer lineages are RUNX1T1, NAXE, and MOSPD1. Each is linked with PIGA in more than 2 cancer types. Because this analysis shows association rather than direction, both PIGA-to-partner and partner-to-PIGA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIGA versus RUNX1T1 in PDAC, with a Pearson correlation of -0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGA→partner) and Y-score (partner→PIGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RUNX1T1 →	-0.741	-0.393	<.001	.002	3	3
OV	NAXE →	+0.593	+0.510	.001	.005	3	3
LUAD	MOSPD1 →	+0.795	+0.470	<.001	<.001	3	2
OV	ABRACL →	+0.848	+0.469	.003	<.001	3	2
OV	MTFR2 →	+0.887	+0.489	.005	.001	3	2
GBM	CLDN14 →	+0.509	+0.326	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,832 associations by consensus.

PIGA vs RUNX1T1 — PDAC

Explore this scatter interactively →