PIGA

Across TCGA patient cohorts, PIGA mutation is significantly associated with the RNA expression of many other genes, with 1,871 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGA-associated genes across cancer lineages are MIR6803, ZIK1P1, and RNA5SP198. Each is linked with PIGA in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGA-to-partner and partner-to-PIGA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6803 grouped by PIGA-low versus PIGA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGA→partner) and Y-score (partner→PIGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6803 →	+0.094	+4.086	<.001	.005	3	2
LUAD	ZIK1P1 →	+0.031	+3.990	<.001	.003	3	2
UCEC	RNA5SP198 →	+0.281	+2.373	.002	.009	3	2
STAD	PRRC2CP1 →	+0.255	+5.035	<.001	.002	3	2
UCEC	BIVM-ERCC5 →	+0.009	+2.257	<.001	<.001	3	2
SKCM	RN7SKP151 →	+0.363	+5.159	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,871 associations by consensus.

MIR6803 by PIGA expression — UCEC

Explore this box plot interactively →