PIGA

Across TCGA patient cohorts, PIGA mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGA-associated genes across cancer lineages are STAT3_pY705, EGFR_pY1068, and EGFR. Each is linked with PIGA in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGA-to-partner and partner-to-PIGA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by PIGA-low versus PIGA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGA→partner) and Y-score (partner→PIGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.397	-1.584	<.001	.036	3	2
UCEC	EGFR_pY1068 →	-0.230	-3.459	.019	.005	3	1
UCEC	EGFR →	-0.198	-2.584	.001	.010	3	1
UCEC	Notch1 →	+0.121	+1.584	.029	.036	3	1
UCEC	p62 Lck ligand →	+0.441	+1.916	<.001	.009	3	1
UCEC	PCNA →	+0.210	+3.459	.013	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

STAT3_pY705 by PIGA expression — UCEC

Explore this box plot interactively →