PIGA

Across TCGA cell cohorts, PIGA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,056 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIGA-associated GO terms across cancer lineages are Establishment of mitotic sister chromatid cohesion, Monoubiquitinated protein deubiquitination, and Regulation of mitotic metaphase/anaphase transition. Each is linked with PIGA in more than 10 cancer types. Because this analysis shows association rather than direction, both PIGA-to-partner and partner-to-PIGA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of mitotic sister chromatid cohesion grouped by PIGA-low versus PIGA-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGA→partner) and Y-score (partner→PIGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Establishment of mitotic sister chromatid cohesion →	+0.108	+0.646	<.001	<.001	3	11
KIDNEY	Monoubiquitinated protein deubiquitination →	+0.098	+0.779	.003	<.001	3	11
KIDNEY	Regulation of mitotic metaphase/anaphase transition →	+0.102	+0.643	.005	.007	3	11
BLOOD_Myeloma	Regulation of sister chromatid cohesion →	+0.105	+0.881	<.001	<.001	3	10
KIDNEY	Regulation of chromosome segregation →	+0.095	+0.704	.002	.004	3	10
LIVER	Nucleus organization →	+0.064	+0.836	.002	.007	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,056 associations by consensus.

Establishment of mitotic sister chromatid cohesion by PIGA expression — LUNG_SCLC

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