PIGA

Across TCGA cell cohorts, PIGA mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIGA-associated genes across cancer lineages are LECT2 and OR10W1. Each is linked with PIGA in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGA-to-partner and partner-to-PIGA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LECT2 grouped by PIGA-low versus PIGA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGA→partner) and Y-score (partner→PIGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LECT2 →	+0.180	+4.196	<.001	.002	3	1
LARGE_INTESTINE	OR10W1 →	+0.015	+4.562	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

LECT2 by PIGA expression — LARGE_INTESTINE

Explore this box plot interactively →