PIFO

Across TCGA patient cohorts, PIFO mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIFO-associated genes across cancer lineages are Caspase-7-cleavedD198, Caspase-8, and p62 Lck ligand. Each is linked with PIFO in more than 1 cancer types. Because this analysis shows association rather than direction, both PIFO-to-partner and partner-to-PIFO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PIFO-low versus PIFO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIFO→partner) and Y-score (partner→PIFO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.867	+2.827	.005	.035	3	1
UCEC	Caspase-8 →	-0.342	-3.321	.009	.010	3	1
UCEC	p62 Lck ligand →	+0.457	+3.009	.007	.019	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Caspase-7-cleavedD198 by PIFO expression — UCEC

Explore this box plot interactively →