PIFO

Across TCGA cell cohorts, PIFO RNA expression is significantly associated with the go_rna of many other GO terms, with 2,795 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIFO-associated GO terms across cancer lineages are Vacuolar acidification, Vesicle targeting, to, from or within Golgi, and Autophagosome organization. Each is linked with PIFO in more than 8 cancer types. Because this analysis shows association rather than direction, both PIFO-to-partner and partner-to-PIFO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vacuolar acidification grouped by PIFO-low versus PIFO-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIFO→partner) and Y-score (partner→PIFO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Vacuolar acidification →	+0.106	+1.069	<.001	.006	3	9
BLOOD_Leukemia	Vesicle targeting, to, from or within Golgi →	+0.055	+0.192	.001	.001	3	9
BLOOD_Leukemia	Autophagosome organization →	+0.043	+0.205	<.001	<.001	3	8
STOMACH	Positive regulation of TOR signaling →	+0.087	+0.841	<.001	.006	2	9
STOMACH	Sodium ion transport →	-0.063	-0.646	<.001	.004	3	8
BONE	Lysosomal lumen acidification →	+0.084	+0.360	.001	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,795 associations by consensus.

Vacuolar acidification by PIFO expression — URINARY_TRACT

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