PIEZO1P2

Across TCGA pan-cancer cohorts, PIEZO1P2 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of PIEZO1P2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PIEZO1P2 RNA is repressed in tumor relative to normal tissue. In most cancer types PIEZO1P2 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, PRAD, and LUSC are the cancer types where PIEZO1P2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIEZO1P2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.007	.018	2	view →
PRAD	All	All	+0.004	.044	2	view →
LUSC	Male	All	+0.006	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

PIEZO1P2–THCA

Open the THCA breakdown →