PIEZO1

Across TCGA patient cohorts, PIEZO1 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,344 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PIEZO1-associated proteins across cancer lineages are PIEZO1_S1646, PXN, and PIEZO1_S1621. Each is linked with PIEZO1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PIEZO1-to-partner and partner-to-PIEZO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIEZO1 versus PIEZO1_S1646 in LSCC, with a Pearson correlation of 0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PIEZO1→partner) and Y-score (partner→PIEZO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PIEZO1_S1646 →	+0.854	+0.795	<.001	<.001	3	6
GBM	PXN →	+0.352	+0.634	<.001	<.001	3	5
UCEC	PIEZO1_S1621 →	+0.793	+0.822	.005	.005	3	4
GBM	PLAU →	+0.653	+0.461	<.001	<.001	3	4
OV	VIM_S22 →	+0.924	+1.167	<.001	<.001	3	4
OV	ATP5PB →	-0.345	-1.301	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,344 associations by consensus.

PIEZO1 vs PIEZO1_S1646 — LSCC

Explore this scatter interactively →