PIEZO1

Across TCGA patient cohorts, PIEZO1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,284 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PIEZO1-associated genes across cancer lineages are XPA, USP13, and ERRFI1. Each is linked with PIEZO1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PIEZO1-to-partner and partner-to-PIEZO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIEZO1 versus XPA in LSCC, with a Pearson correlation of -0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIEZO1→partner) and Y-score (partner→PIEZO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	XPA →	-0.756	-0.385	<.001	<.001	3	5
LSCC	USP13 →	-0.881	-0.381	<.001	<.001	3	5
OV	ERRFI1 →	+1.040	+0.431	.004	.001	3	4
HNSC	TUBG1P →	-0.489	-0.301	.001	<.001	3	4
GBM	MAGI1 →	-0.796	-0.321	.001	.006	3	4
PDAC	FPR2 →	+0.952	+0.753	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,284 associations by consensus.

PIEZO1 vs XPA — LSCC

Explore this scatter interactively →