PIEZO1

Across TCGA patient cohorts, PIEZO1 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIEZO1-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and eIF4E. Each is linked with PIEZO1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PIEZO1-to-partner and partner-to-PIEZO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PIEZO1-low versus PIEZO1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIEZO1→partner) and Y-score (partner→PIEZO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.038	+3.338	<.001	.004	3	3
UCEC	EGFR_pY1068 →	-0.181	-0.912	.005	.032	3	2
COAD	eIF4E →	+0.182	+2.182	.009	.033	3	2
UCEC	MEK1 →	+0.297	+2.392	.001	<.001	3	2
UCEC	MSH2 →	-0.190	-1.414	.001	.020	3	2
UCEC	PDCD4 →	-0.329	-1.321	.007	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Caspase-7-cleavedD198 by PIEZO1 expression — COAD

Explore this box plot interactively →