PIEZO1

Across TCGA cell cohorts, PIEZO1 RNA expression is significantly associated with the RNA expression of many other genes, with 10,708 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIEZO1-associated genes across cancer lineages are TCF25, CENPT, and DHX38. Each is linked with PIEZO1 in more than 16 cancer types. Because this analysis shows association rather than direction, both PIEZO1-to-partner and partner-to-PIEZO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIEZO1 versus TCF25 in BONE, with a Pearson correlation of 0.72.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIEZO1→partner) and Y-score (partner→PIEZO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TCF25 →	+1.092	+1.548	<.001	<.001	3	17
URINARY_TRACT	CENPT →	+0.939	+1.119	<.001	<.001	2	15
BONE	DHX38 →	+1.028	+1.694	<.001	<.001	3	14
BONE	ZNF276 →	+1.501	+1.694	<.001	<.001	3	14
BONE	ANKRD11 →	+1.195	+1.591	<.001	<.001	3	14
BONE	SPG7 →	+1.170	+1.765	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,708 associations by consensus.

PIEZO1 vs TCF25 — BONE

Explore this scatter interactively →