PIEZO1

Across TCGA cell cohorts, PIEZO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,470 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIEZO1-associated GO terms across cancer lineages are Multi-pass transmembrane protein insertion into ER membrane, Regulation of plasma membrane repair, and Assembly of actomyosin apparatus involved in cytokinesis. Each is linked with PIEZO1 in more than 12 cancer types. Because this analysis shows association rather than direction, both PIEZO1-to-partner and partner-to-PIEZO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Multi-pass transmembrane protein insertion into ER membrane grouped by PIEZO1-low versus PIEZO1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIEZO1→partner) and Y-score (partner→PIEZO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Multi-pass transmembrane protein insertion into ER membrane →	+0.151	+1.972	<.001	<.001	3	13
BONE	Regulation of plasma membrane repair →	+0.307	+1.091	.001	.004	3	12
SOFT_TISSUE	Assembly of actomyosin apparatus involved in cytokinesis →	+0.167	+1.453	<.001	<.001	3	11
SOFT_TISSUE	Actomyosin contractile ring assembly →	+0.167	+1.453	<.001	<.001	3	11
CNS	Regulation of cell-substrate adhesion →	+0.046	+0.480	<.001	.003	3	11
BONE	Actomyosin contractile ring assembly actin filament organization →	+0.274	+1.506	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,470 associations by consensus.

Multi-pass transmembrane protein insertion into ER membrane by PIEZO1 expression — BONE

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