PIEZO1

Across TCGA cell cohorts, PIEZO1 mutation is significantly associated with the RNA expression of many other genes, with 736 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIEZO1-associated genes across cancer lineages are BRD1, ATF4, and ZUP1. Each is linked with PIEZO1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PIEZO1-to-partner and partner-to-PIEZO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRD1 grouped by PIEZO1-low versus PIEZO1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIEZO1→partner) and Y-score (partner→PIEZO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BRD1 →	+0.469	+3.459	<.001	<.001	3	3
LARGE_INTESTINE	ATF4 →	+0.655	+2.130	<.001	<.001	3	3
LARGE_INTESTINE	ZUP1 →	+0.530	+3.321	.001	.002	3	3
LARGE_INTESTINE	THAP9 →	+0.482	+2.546	<.001	.001	3	3
LARGE_INTESTINE	NOP58 →	+0.422	+1.721	<.001	.003	3	3
LARGE_INTESTINE	MTHFD2 →	+0.776	+2.130	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 736 associations by consensus.

BRD1 by PIEZO1 expression — LARGE_INTESTINE

Explore this box plot interactively →