PIDD1

Across TCGA patient cohorts, PIDD1 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIDD1-associated genes across cancer lineages are PCNA, A-Raf_pS299, and ATM. Each is linked with PIDD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PIDD1-to-partner and partner-to-PIDD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PIDD1-low versus PIDD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIDD1→partner) and Y-score (partner→PIDD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.275	+2.584	.002	.010	3	3
UCEC	A-Raf_pS299 →	-0.193	-2.222	<.001	.011	3	3
UCEC	ATM →	-0.779	-4.000	<.001	<.001	3	3
BLCA	c-Kit →	-0.356	-3.000	.044	.036	3	2
UCEC	eIF4E →	+0.224	+3.584	.012	.002	3	2
UCEC	mTOR_pS2448 →	-0.164	-3.439	.009	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

PCNA by PIDD1 expression — UCEC

Explore this box plot interactively →