PIDD1

Across TCGA cell cohorts, PIDD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,086 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIDD1-associated GO terms across cancer lineages are Methylglyoxal metabolic process, Cellular detoxification of methylglyoxal, and Response to methylglyoxal. Each is linked with PIDD1 in more than 16 cancer types. Because this analysis shows association rather than direction, both PIDD1-to-partner and partner-to-PIDD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Methylglyoxal metabolic process grouped by PIDD1-low versus PIDD1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIDD1→partner) and Y-score (partner→PIDD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Methylglyoxal metabolic process →	+0.136	+1.045	.002	.002	3	17
OESOPHAGUS	Cellular detoxification of methylglyoxal →	+0.162	+1.545	<.001	<.001	3	16
OESOPHAGUS	Response to methylglyoxal →	+0.162	+1.545	<.001	<.001	3	16
OESOPHAGUS	Methylglyoxal catabolic process →	+0.196	+1.729	<.001	<.001	3	16
OESOPHAGUS	Cellular response to methylglyoxal →	+0.162	+1.545	<.001	<.001	3	16
BONE	Positive regulation of double-strand break repair →	+0.104	+1.499	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,086 associations by consensus.

Methylglyoxal metabolic process by PIDD1 expression — OESOPHAGUS

Explore this box plot interactively →