PICK1

Across TCGA pan-cancer cohorts, PICK1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PICK1 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PICK1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PICK1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, PDAC, and LUAD are the cancer types where PICK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.968	0.801	.006	32	view →
PDAC	DFS	Median	II,III,IV	0.850	0.615	.007	23	view →
LUAD	DFS	Quartile	II,III,IV	0.256	0.605	.006	13	view →
GBM	DFS	Tertile	All	0.862	0.596	.009	5	view →
LSCC	OS	Quartile	All	0.669	0.910	.031	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PICK1–UCEC (DFS)

Open the UCEC breakdown →