PICK1

Across TCGA patient cohorts, PICK1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,268 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PICK1-associated genes across cancer lineages are ICA1, ARFGEF3, and MLPH. Each is linked with PICK1 in more than 9 cancer types. Because this analysis shows association rather than direction, both PICK1-to-partner and partner-to-PICK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PICK1 versus ICA1 in LSCC, with a Pearson correlation of 0.79.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PICK1→partner) and Y-score (partner→PICK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ICA1 →	+1.280	+0.465	<.001	<.001	3	10
HNSC	ARFGEF3 →	+1.372	+0.435	<.001	<.001	3	7
BRCA	MLPH →	+1.596	+0.309	<.001	<.001	3	6
UCEC	ELAPOR1 →	+1.854	+0.263	<.001	<.001	3	6
UCEC	TFF3 →	+3.633	+0.318	<.001	.006	3	6
LSCC	TMC5 →	+2.129	+0.530	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,268 associations by consensus.

PICK1 vs ICA1 — LSCC

Explore this scatter interactively →