PICK1

Across TCGA patient cohorts, PICK1 mutation is significantly associated with the RNA expression of many other genes, with 572 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PICK1-associated genes across cancer lineages are TXNL4AP1, RPS10P21, and RNU1-17P. Each is linked with PICK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PICK1-to-partner and partner-to-PICK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXNL4AP1 grouped by PICK1-low versus PICK1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PICK1→partner) and Y-score (partner→PICK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TXNL4AP1 →	+0.204	+3.951	.003	.005	3	2
SKCM	RPS10P21 →	+0.071	+4.097	<.001	.002	3	2
UCEC	RNU1-17P →	+0.289	+2.935	<.001	.001	3	2
UCEC	RN7SL447P →	+0.197	+2.418	<.001	.005	3	2
UCEC	DOC2B →	-1.192	-3.459	.001	.005	3	1
UCEC	TAF9 →	+0.654	+2.700	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 572 associations by consensus.

TXNL4AP1 by PICK1 expression — COAD

Explore this box plot interactively →