PICK1

Across TCGA patient cohorts, PICK1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PICK1-associated genes across cancer lineages are EGFR, Ku80, and MAPK_pT202_Y204. Each is linked with PICK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PICK1-to-partner and partner-to-PICK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by PICK1-low versus PICK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PICK1→partner) and Y-score (partner→PICK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.175	-2.321	.029	.035	3	1
UCEC	Ku80 →	+0.320	+2.335	.006	.020	3	1
UCEC	MAPK_pT202_Y204 →	-0.572	-2.321	.015	.034	3	1
UCEC	p62 Lck ligand →	+0.338	+2.321	.038	.035	3	1
UCEC	p90 RSK_pT359_S363 →	-0.240	-2.321	.018	.035	3	1
UCEC	PDK1_pS241 →	+0.224	+2.335	.009	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

EGFR by PICK1 expression — UCEC

Explore this box plot interactively →