PICK1

Across TCGA cell cohorts, PICK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,785 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PICK1-associated GO terms across cancer lineages are Negative regulation of Arp2/3 complex-mediated actin nucleation, Cilium or flagellum-dependent cell motility, and Cilium-dependent cell motility. Each is linked with PICK1 in more than 14 cancer types. Because this analysis shows association rather than direction, both PICK1-to-partner and partner-to-PICK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of Arp2/3 complex-mediated actin nucleation grouped by PICK1-low versus PICK1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PICK1→partner) and Y-score (partner→PICK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.321	+1.230	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.100	-0.782	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Cilium-dependent cell motility →	-0.100	-0.782	<.001	<.001	3	13
LIVER	Negative regulation of actin nucleation →	+0.229	+0.984	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Cilium movement →	-0.083	-1.110	<.001	<.001	3	12
KIDNEY	Positive regulation of sphingolipid biosynthetic process →	+0.147	+1.596	.001	.005	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,785 associations by consensus.

Negative regulation of Arp2/3 complex-mediated actin nucleation by PICK1 expression — LIVER

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