PIAS4

Across TCGA pan-cancer cohorts, PIAS4 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of PIAS4’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where PIAS4 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PIAS4 is over-expressed in tumor.

LSCC and CCRCC are the cancer types where PIAS4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIAS4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	+0.283	<.001	6	view →
CCRCC	Male	All	+0.179	.006	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

PIAS4–LSCC

Open the LSCC breakdown →