PIAS3

Across TCGA patient cohorts, PIAS3 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,292 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PIAS3-associated proteins across cancer lineages are PIK3R4_S853, PLCL2_S1113, and DOCK2_S1706. Each is linked with PIAS3 in more than 4 cancer types. Because this analysis shows association rather than direction, both PIAS3-to-partner and partner-to-PIAS3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIAS3 versus PIK3R4_S853 in UCEC, with a Pearson correlation of -0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PIAS3→partner) and Y-score (partner→PIAS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PIK3R4_S853 →	-0.618	-0.441	<.001	.001	3	5
LSCC	PLCL2_S1113 →	-0.529	-0.503	<.001	<.001	3	5
LUAD	DOCK2_S1706 →	-0.636	-0.482	.002	.001	3	5
LSCC	FLI1_S39 →	-0.520	-0.691	.001	<.001	3	5
LSCC	SPCS3 →	-0.498	-0.694	<.001	<.001	3	5
BRCA	NOS1AP →	+0.694	+0.752	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,292 associations by consensus.

PIAS3 vs PIK3R4_S853 — UCEC

Explore this scatter interactively →