PIAS3

Across TCGA patient cohorts, PIAS3 mutation is significantly associated with the immune_cell of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIAS3-associated genes across cancer lineages are Endothelial cells, Adipocytes, and Eosinophils. Each is linked with PIAS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIAS3-to-partner and partner-to-PIAS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endothelial cells grouped by PIAS3-low versus PIAS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIAS3→partner) and Y-score (partner→PIAS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Endothelial cells →	-0.031	-1.991	.017	.031	3	2
LUSC	Adipocytes →	+0.019	+3.183	.021	.032	3	1
LUSC	Eosinophils →	+0.030	+2.588	.009	.036	3	1
COAD	Macrophages →	+0.020	+1.966	.002	.023	3	1
COAD	Macrophages M1 →	+0.019	+2.832	.024	.049	3	1
SKCM	GMP →	+0.030	+2.221	.033	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Endothelial cells by PIAS3 expression — UCEC

Explore this box plot interactively →