PIAS3

Across TCGA cell cohorts, PIAS3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,498 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIAS3-associated GO terms across cancer lineages are Negative regulation of protein sumoylation, Golgi vesicle transport, and Negative regulation of cilium assembly. Each is linked with PIAS3 in more than 19 cancer types. Because this analysis shows association rather than direction, both PIAS3-to-partner and partner-to-PIAS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein sumoylation grouped by PIAS3-low versus PIAS3-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIAS3→partner) and Y-score (partner→PIAS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of protein sumoylation →	+0.158	+1.167	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Golgi vesicle transport →	+0.075	+1.009	<.001	<.001	3	14
LIVER	Negative regulation of cilium assembly →	+0.071	+1.138	.002	.004	3	13
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.064	+0.830	.002	.004	2	14
LARGE_INTESTINE	Negative regulation of calcium ion export across plasma membrane →	+0.067	+1.096	<.001	<.001	3	13
STOMACH	Golgi to plasma membrane transport →	+0.115	+1.173	.001	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,498 associations by consensus.

Negative regulation of protein sumoylation by PIAS3 expression — STOMACH

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