PIAS3

Across TCGA cell cohorts, PIAS3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIAS3-associated genes across cancer lineages are TAFA1, NAT8B, and MYMX. Each is linked with PIAS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIAS3-to-partner and partner-to-PIAS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAFA1 grouped by PIAS3-low versus PIAS3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIAS3→partner) and Y-score (partner→PIAS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
LARGE_INTESTINE	NAT8B →	+0.631	+3.667	.009	.003	3	1
LARGE_INTESTINE	MYMX →	+0.356	+3.551	<.001	.004	3	1
BREAST	REG1B →	+1.039	+5.169	<.001	.005	3	1
BLOOD_Leukemia	AMELX →	+0.028	+4.539	<.001	.007	3	1
LARGE_INTESTINE	FAM153B →	+0.484	+3.618	<.001	.003	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

TAFA1 by PIAS3 expression — LARGE_INTESTINE

Explore this box plot interactively →