PIAS2

Across TCGA patient cohorts, PIAS2 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,195 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PIAS2-associated proteins across cancer lineages are SMAD4, VRK1, and ZNF687. Each is linked with PIAS2 in more than 7 cancer types. Because this analysis shows association rather than direction, both PIAS2-to-partner and partner-to-PIAS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIAS2 versus SMAD4 in PDAC, with a Pearson correlation of 0.47.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PIAS2→partner) and Y-score (partner→PIAS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SMAD4 →	+0.316	+0.389	<.001	<.001	3	8
GBM	VRK1 →	+0.481	+0.441	.001	<.001	3	5
LSCC	ZNF687 →	+0.409	+0.666	<.001	<.001	3	5
GBM	IPO9 →	+0.398	+0.539	<.001	<.001	3	5
GBM	RFC3 →	+0.303	+0.399	<.001	<.001	3	5
LSCC	RPRD1A →	+0.416	+0.633	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,195 associations by consensus.

PIAS2 vs SMAD4 — PDAC

Explore this scatter interactively →