PIAS2

Across TCGA patient cohorts, PIAS2 protein abundance is significantly associated with the RNA expression of many other genes, with 16,100 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PIAS2-associated genes across cancer lineages are SRSF3, RIOK1, and CCDC59. Each is linked with PIAS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PIAS2-to-partner and partner-to-PIAS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIAS2 versus SRSF3 in GBM, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIAS2→partner) and Y-score (partner→PIAS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SRSF3 →	+0.470	+0.335	<.001	<.001	3	4
LSCC	RIOK1 →	+0.535	+0.291	<.001	.003	3	4
LSCC	CCDC59 →	+0.362	+0.262	.004	.005	3	4
GBM	C18orf21 →	+0.483	+0.341	<.001	.001	3	4
LSCC	INTS13 →	+0.495	+0.436	.003	<.001	3	4
UCEC	PUS7 →	+0.594	+0.230	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,100 associations by consensus.

PIAS2 vs SRSF3 — GBM

Explore this scatter interactively →