PIAS2

Across TCGA cell cohorts, PIAS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,651 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIAS2-associated GO terms across cancer lineages are Heterochromatin organization, Microtubule polymerization, and Regulation of chromosome condensation. Each is linked with PIAS2 in more than 16 cancer types. Because this analysis shows association rather than direction, both PIAS2-to-partner and partner-to-PIAS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heterochromatin organization grouped by PIAS2-low versus PIAS2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIAS2→partner) and Y-score (partner→PIAS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Heterochromatin organization →	+0.066	+0.594	<.001	.007	3	17
BLOOD_Leukemia	Microtubule polymerization →	+0.085	+0.647	<.001	<.001	3	15
STOMACH	Regulation of chromosome condensation →	+0.208	+1.272	<.001	<.001	3	15
LARGE_INTESTINE	Positive regulation of DNA metabolic process →	+0.061	+1.328	<.001	<.001	3	15
BREAST	Microtubule cytoskeleton organization involved in mitosis →	+0.081	+0.983	<.001	<.001	3	15
OVARY	Negative regulation of gene expression, epigenetic →	+0.056	+0.850	.005	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,651 associations by consensus.

Heterochromatin organization by PIAS2 expression — LIVER

Explore this box plot interactively →