PIAS2

Across TCGA cell cohorts, PIAS2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PIAS2-associated genes across cancer lineages are OR1L6, URAD, and LIPN. Each is linked with PIAS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIAS2-to-partner and partner-to-PIAS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L6 grouped by PIAS2-low versus PIAS2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIAS2→partner) and Y-score (partner→PIAS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR1L6 →	+0.035	+5.029	<.001	.006	3	1
LUNG_SCLC	URAD →	+0.044	+5.029	<.001	.006	3	1
LUNG_SCLC	LIPN →	+0.086	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR1L6 by PIAS2 expression — LUNG_SCLC

Explore this box plot interactively →