PIAS1

Across TCGA pan-cancer cohorts, PIAS1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PIAS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PIAS1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PIAS1 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and CCRCC are the cancer types where PIAS1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIAS1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	−0.208	.007	8	view →
LUAD	Female	All	−0.190	<.001	6	view →
CCRCC	All	All	+0.155	.003	5	view →
PDAC	All	All	+0.368	.011	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PIAS1–HNSC

Open the HNSC breakdown →