PIANP

Across TCGA patient cohorts, PIANP mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIANP-associated genes across cancer lineages are FASN, IGFBP2, and Src. Each is linked with PIANP in more than 1 cancer types. Because this analysis shows association rather than direction, both PIANP-to-partner and partner-to-PIANP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by PIANP-low versus PIANP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIANP→partner) and Y-score (partner→PIANP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.564	+2.584	.002	.011	3	1
UCEC	IGFBP2 →	-0.847	-2.999	.005	.035	3	1
UCEC	Src →	+0.216	+3.000	.024	.036	3	1
UCEC	TIGAR →	+0.195	+1.901	.006	.031	3	1
UCEC	Tuberin →	+0.286	+3.331	.022	.005	3	1
UCEC	Caveolin-1 →	-0.670	-3.169	.047	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

FASN by PIANP expression — UCEC

Explore this box plot interactively →