PI4KA

Across TCGA pan-cancer cohorts, PI4KA mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PI4KA’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PI4KA mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PI4KA is over-expressed in tumor, although a few such as CCRCC and COAD show the opposite, repressed pattern.

CCRCC, COAD, and LUAD are the cancer types where PI4KA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PI4KA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	−0.386	<.001	12	view →
COAD	Male	III,IV	−0.371	<.001	11	view →
LUAD	Male	III,IV	−0.307	<.001	8	view →
LSCC	Female	II,III,IV	−0.294	<.001	8	view →
HNSC	All	IV	+0.115	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PI4KA–CCRCC

Open the CCRCC breakdown →