PI4K2B

Across TCGA pan-cancer cohorts, PI4K2B mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PI4K2B data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PI4K2B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PI4K2B expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, CCRCC, and GBM are the cancer types where PI4K2B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	All	1.000	0.758	.002	18	view →
CCRCC	DFS	Tertile	All	0.847	0.559	.006	16	view →
GBM	DFS	Median	All	0.592	0.878	<.001	16	view →
LSCC	OS	Tertile	III,IV	0.588	0.986	.015	8	view →
PDAC	OS	Median	IV	0.395	0.934	.024	7	view →
LUAD	OS	Median	III,IV	0.748	0.490	.048	2	view →
HNSC	DFS	Median	III,IV	1.000	0.939	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PI4K2B–UCEC (OS)

Open the UCEC breakdown →