PI4K2B

Across TCGA patient cohorts, PI4K2B RNA expression is significantly associated with the go_rna of many other GO terms, with 7,163 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PI4K2B-associated GO terms across cancer lineages are Positive regulation of chromosome segregation, Regulation of chromosome condensation, and Positive regulation of chromosome condensation. Each is linked with PI4K2B in more than 29 cancer types. Because this analysis shows association rather than direction, both PI4K2B-to-partner and partner-to-PI4K2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of chromosome segregation grouped by PI4K2B-low versus PI4K2B-high in LAML.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PI4K2B→partner) and Y-score (partner→PI4K2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	Positive regulation of chromosome segregation →	+0.087	+0.573	<.001	<.001	3	30
LAML	Regulation of chromosome condensation →	+0.088	+0.518	<.001	<.001	3	30
DLBC	Positive regulation of chromosome condensation →	+0.119	+0.687	<.001	<.001	3	30
UVM	Interstrand cross-link repair →	+0.052	+1.223	<.001	<.001	3	29
DLBC	Meiotic chromosome condensation →	+0.112	+0.765	<.001	<.001	3	28
LAML	Centriole-centriole cohesion →	+0.055	+0.497	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,163 associations by consensus.

Positive regulation of chromosome segregation by PI4K2B expression — LAML

Explore this box plot interactively →