PI4K2B

Across TCGA patient cohorts, PI4K2B mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PI4K2B-associated genes across cancer lineages are Akt_pT308, EGFR, and FASN. Each is linked with PI4K2B in more than 1 cancer types. Because this analysis shows association rather than direction, both PI4K2B-to-partner and partner-to-PI4K2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by PI4K2B-low versus PI4K2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PI4K2B→partner) and Y-score (partner→PI4K2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.664	+2.321	.019	.034	3	2
UCEC	EGFR →	-0.190	-2.000	.008	.032	3	1
UCEC	FASN →	+0.487	+3.169	.006	.019	2	2
UCEC	FoxM1 →	+0.259	+3.807	.026	<.001	3	1
UCEC	GATA6 →	-0.200	-2.459	.003	.019	3	1
UCEC	MEK1 →	+0.618	+3.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Akt_pT308 by PI4K2B expression — UCEC

Explore this box plot interactively →