PI4K2A

Across TCGA pan-cancer cohorts, PI4K2A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PI4K2A data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PI4K2A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PI4K2A expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where PI4K2A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.696	0.470	.009	17	view →
LSCC	DFS	Median	II,III,IV	0.879	0.667	.009	13	view →
PDAC	DFS	Tertile	III,IV	0.305	0.962	.017	10	view →
CCRCC	DFS	Tertile	All	1.000	0.901	.020	5	view →
GBM	OS	Quartile	All	0.398	0.638	.019	2	view →
LUAD	DFS	Median	All	0.720	0.459	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PI4K2A–HNSC (DFS)

Open the HNSC breakdown →