PI4K2A

Across TCGA patient cohorts, PI4K2A protein abundance is significantly associated with the RNA expression of many other genes, with 8,692 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PI4K2A-associated genes across cancer lineages are EIF2B5, METTL17, and ZNF507. Each is linked with PI4K2A in more than 4 cancer types. Because this analysis shows association rather than direction, both PI4K2A-to-partner and partner-to-PI4K2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PI4K2A versus EIF2B5 in HNSC, with a Pearson correlation of -0.22.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PI4K2A→partner) and Y-score (partner→PI4K2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EIF2B5 →	-0.738	-0.239	<.001	.006	3	5
COAD	METTL17 →	-0.560	-0.434	<.001	.003	3	4
COAD	ZNF507 →	-0.534	-0.336	.002	.003	3	4
LSCC	TADA1 →	-0.604	-0.163	<.001	.008	3	4
GBM	FOLR2 →	+1.144	+0.382	<.001	<.001	3	4
GBM	GPX1 →	+0.484	+0.337	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,692 associations by consensus.

PI4K2A vs EIF2B5 — HNSC

Explore this scatter interactively →