PI4K2A

Across TCGA patient cohorts, PI4K2A mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PI4K2A-associated genes across cancer lineages are ATM, Bax, and Beclin. Each is linked with PI4K2A in more than 1 cancer types. Because this analysis shows association rather than direction, both PI4K2A-to-partner and partner-to-PI4K2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PI4K2A-low versus PI4K2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PI4K2A→partner) and Y-score (partner→PI4K2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.707	-3.687	<.001	.001	3	2
UCEC	Bax →	+0.205	+1.884	.033	.030	3	2
UCEC	Beclin →	-0.076	-3.169	.046	.018	3	2
UCEC	c-Kit →	-0.201	-1.906	.032	.016	3	2
UCEC	EGFR_pY1068 →	-0.338	-2.700	<.001	.006	3	1
UCEC	eIF4E →	+0.201	+2.415	.017	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ATM by PI4K2A expression — UCEC

Explore this box plot interactively →