PI4K2A

Across TCGA cell cohorts, PI4K2A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,986 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PI4K2A-associated GO terms across cancer lineages are Phosphatidylinositol biosynthetic process, Protein localization to endosome, and Negative regulation of smoothened signaling pathway. Each is linked with PI4K2A in more than 14 cancer types. Because this analysis shows association rather than direction, both PI4K2A-to-partner and partner-to-PI4K2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Phosphatidylinositol biosynthetic process grouped by PI4K2A-low versus PI4K2A-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PI4K2A→partner) and Y-score (partner→PI4K2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Phosphatidylinositol biosynthetic process →	+0.067	+1.031	<.001	<.001	3	14
BONE	Protein localization to endosome →	+0.205	+0.647	<.001	<.001	3	14
LUNG_SCLC	Negative regulation of smoothened signaling pathway →	+0.054	+0.626	<.001	.002	2	15
BONE	Regulation of cell-substrate adhesion →	+0.134	+0.647	<.001	<.001	3	13
STOMACH	Regulation of early endosome to late endosome transport →	+0.140	+1.334	<.001	<.001	3	13
LUNG_NSCLC_LUAD	COPI-coated vesicle budding →	+0.109	+0.732	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,986 associations by consensus.

Phosphatidylinositol biosynthetic process by PI4K2A expression — LIVER

Explore this box plot interactively →