PI3

Across TCGA pan-cancer cohorts, PI3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PI3 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PI3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PI3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where PI3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.932	0.762	.001	72	view →
LSCC	DFS	Median	II,III,IV	0.485	1.000	.006	5	view →
PDAC	OS	Quartile	II,III,IV	0.666	0.298	.015	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PI3–HNSC (OS)

Open the HNSC breakdown →