PI3

Across TCGA patient cohorts, PI3 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,485 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PI3-associated proteins across cancer lineages are LCN2, S100A9, and CSTA. Each is linked with PI3 in more than 8 cancer types. Because this analysis shows association rather than direction, both PI3-to-partner and partner-to-PI3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PI3 versus LCN2 in GBM, with a Pearson correlation of 0.75.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PI3→partner) and Y-score (partner→PI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LCN2 →	+1.482	+2.675	<.001	<.001	3	9
BRCA	S100A9 →	+1.484	+2.073	<.001	<.001	3	7
HNSC	CSTA →	+1.371	+3.451	<.001	<.001	3	7
UCEC	KRT17 →	+1.134	+2.113	<.001	<.001	3	6
GBM	S100A12 →	+1.391	+2.388	<.001	<.001	3	6
BRCA	S100A8 →	+1.647	+1.999	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,485 associations by consensus.

PI3 vs LCN2 — GBM

Explore this scatter interactively →