PI3

Across TCGA patient cohorts, PI3 protein abundance is significantly associated with the RNA expression of many other genes, with 11,180 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PI3-associated genes across cancer lineages are S100A8, S100A9, and PERP. Each is linked with PI3 in more than 4 cancer types. Because this analysis shows association rather than direction, both PI3-to-partner and partner-to-PI3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PI3 versus S100A8 in UCEC, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PI3→partner) and Y-score (partner→PI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S100A8 →	+3.263	+2.072	<.001	<.001	3	5
UCEC	S100A9 →	+3.938	+2.105	<.001	<.001	3	5
LSCC	PERP →	+0.825	+1.459	.002	<.001	3	4
LSCC	CSTA →	+1.941	+1.647	<.001	<.001	3	4
HNSC	S100A12 →	+2.437	+1.586	<.001	<.001	3	4
BRCA	S100A7 →	+4.294	+0.977	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,180 associations by consensus.

PI3 vs S100A8 — UCEC

Explore this scatter interactively →