PI3

Across TCGA patient cohorts, PI3 mutation is significantly associated with the RNA expression of many other genes, with 107 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PI3-associated genes across cancer lineages are RN7SKP250, LINC01017, and IGKV2-18. Each is linked with PI3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PI3-to-partner and partner-to-PI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP250 grouped by PI3-low versus PI3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PI3→partner) and Y-score (partner→PI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP250 →	+0.314	+3.198	<.001	.009	3	2
UCEC	LINC01017 →	+0.109	+3.294	<.001	.007	3	2
UCEC	IGKV2-18 →	+0.413	+2.747	.001	.009	3	2
LUSC	OR4K17 →	+0.109	+6.191	<.001	.001	3	2
COAD	OR8J1 →	+0.074	+7.741	<.001	.009	3	1
UCEC	LINC01050 →	+0.238	+3.064	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 107 associations by consensus.

RN7SKP250 by PI3 expression — UCEC

Explore this box plot interactively →