PI3

Across TCGA patient cohorts, PI3 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PI3-associated genes across cancer lineages are Platelets, DC, and B-cells. Each is linked with PI3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PI3-to-partner and partner-to-PI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Platelets grouped by PI3-low versus PI3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PI3→partner) and Y-score (partner→PI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Platelets →	+0.033	+2.148	<.001	.041	3	2
UCEC	DC →	+0.028	+2.871	.027	.034	3	1
UCEC	B-cells →	+0.042	+2.310	.010	.026	3	1
UCEC	aDC →	+0.164	+2.818	<.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Platelets by PI3 expression — UCEC

Explore this box plot interactively →