PI3

Across TCGA cell cohorts, PI3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,971 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PI3-associated GO terms across cancer lineages are Complement activation, lectin pathway, Copulation, and Viral process. Each is linked with PI3 in more than 10 cancer types. Because this analysis shows association rather than direction, both PI3-to-partner and partner-to-PI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Complement activation, lectin pathway grouped by PI3-low versus PI3-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PI3→partner) and Y-score (partner→PI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Complement activation, lectin pathway →	+1.443	+3.059	.002	.004	3	11
LUNG_NSCLC_LUSC	Copulation →	+2.015	+7.122	<.001	<.001	3	10
BREAST	Viral process →	+0.053	+2.084	.002	.003	3	10
BREAST	Response to mycotoxin →	+0.570	+4.240	.002	<.001	3	9
STOMACH	Microtubule bundle formation →	-0.051	-2.801	<.001	<.001	3	9
OESOPHAGUS	Negative regulation of molecular function →	+0.065	+4.515	.002	.005	1	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,971 associations by consensus.

Complement activation, lectin pathway by PI3 expression — URINARY_TRACT

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