PI16

Across TCGA patient cohorts, PI16 mutation is significantly associated with the RNA expression of many other genes, with 706 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PI16-associated genes across cancer lineages are CDKN3, MLX, and STAG3L4. Each is linked with PI16 in more than 1 cancer types. Because this analysis shows association rather than direction, both PI16-to-partner and partner-to-PI16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDKN3 grouped by PI16-low versus PI16-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PI16→partner) and Y-score (partner→PI16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CDKN3 →	+0.713	+3.208	.001	.009	3	2
SKCM	MLX →	+0.394	+3.373	.003	.004	3	2
UCEC	STAG3L4 →	+0.690	+2.700	<.001	.006	3	2
UCEC	NCAPH2 →	+0.640	+3.491	<.001	.002	3	2
UCEC	LINC02528 →	+0.448	+2.807	<.001	.001	3	2
LUAD	OR2B3 →	+0.116	+5.087	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 706 associations by consensus.

CDKN3 by PI16 expression — SKCM

Explore this box plot interactively →