PI16

Across TCGA patient cohorts, PI16 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PI16-associated genes across cancer lineages are p38-MAPK_pT180_Y182, p62 Lck ligand, and ATM. Each is linked with PI16 in more than 1 cancer types. Because this analysis shows association rather than direction, both PI16-to-partner and partner-to-PI16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by PI16-low versus PI16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PI16→partner) and Y-score (partner→PI16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.453	-3.000	.045	.036	3	2
UCEC	p62 Lck ligand →	+0.386	+3.331	.018	.005	3	2
UCEC	ATM →	-0.799	-3.308	<.001	.009	3	2
SKCM	NDRG1_pT346 →	-0.797	-3.000	.035	.036	3	1
SKCM	AMPK_pT172 →	+0.371	+3.000	.049	.036	3	1
UCEC	ERK2 →	+0.310	+2.999	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

p38-MAPK_pT180_Y182 by PI16 expression — UCEC

Explore this box plot interactively →